Abstract #4089

Is Increased Normal White Matter Glutamate Concentrations a Precursor of Gliosis & Disease Progression in Multiple Sclerosis?

Olof Dahlqvist Leinhard^1,2, Jacek Jaworski³, Anne Aalto⁴, Anders Grnqvist⁵, Anders Tisell^1,2, rjan Smedby^2,4, Anne-Marie Landtblom^3,6, Peter Lundberg^5,7

¹Dept of Radiation physics (IMH), Linkping University, Linkping, Sweden; ²Center for Medical Image Science & Visualization (CMIV), Linkping University, Linkping, Sweden; ³Department of Neurology, Linkping University Hospital, Linkping, Sweden; ⁴Dept of Radiology (IMH), Linkping University, Linkping, Sweden; ⁵Dept of Radiation Physics (CKOC), Linkping University Hospital, Linkping, Sweden; ⁶Division of Clinical Immunology, Unit of Autoimmunity and Immune Regulation (IKE), Linkping University, Linkping, Sweden; ⁷Dept of Radiation physics (IMH), Center for Medical Image Science & Visualization (CMIV), Linkping University, Linkping, Sweden

Multiple sclerosis (MS) severity scale (MSSS) and expanded disability status (EDSS) were correlated to absolute concentrations of cerebral metabolites N-acetylaspartat (NAA), Creatine (Cr), and glutamate Glu. 108 examinations of 48 patients were included in the study.