Abstract #4072

Non-Invasive Detection of Microvascular Remodeling Enhanced by Erythropoietin Treatment in a Rat Model of Focal Ischemia using MRI

Asamoah Bosomtwi¹, Michael Chopp^2,3, Guang Liang Ding², Li Zhang², Leonard L. Howell¹, Quan Jiang²

¹Yerkes Primate Center, Emory University, Atlanta, GA, United States; ²Neurology, Henry Ford Hospital; ³Physics, Oakland University

We investigated vascular remodeling after stroke and dynamically monitor these changes using MRI microvascular density (MVD), MRI mean vessel size (VSI) and MRI mean segment length (MSL). We demonstrate that MRI parameters can detect the microvascular status of brain tissue and evaluate the efficacy of erythropoietin (EPO) treatment.