Aging Effect on the Resting State: Two Complementary Approaches with the Same fMRI Datasets

Makoto Miyakoshi¹, Satoru Miyauchi², Takahiko Koike², Shigeyuki Kan², Toshiharu Nakai¹

The present study aimed to investigate the aging brain with two different approaches, the alpha-power correlation and functional connectivity by simultaneous EEG-fMRI recording. Extracting alpha band activity with temporal ICA on EEG was successful with the young but not with the old. Alpha-power correlated regions of the young thus suggest regions that are subject to age-related changes, which is probably due to degeneration of temporal organization of alpha-band activity. Functional connectivity analyses identified the corresponding network in the old, whose spatial pattern is nonetheless altered to be diffusive. This alternation may be responsible for the emissingf alpha-band activity.