Abstract #4006

Combined Dynamic Susceptibilty Contrast (DSC) Imaging & Arterial Spin Labeling (ASL) for Quantitative Perfusion Measurements in Children with Diffuse Pontine Glioma

Brian A. Taylor¹, Adam Winchell^1,2, Jan Sedlacik¹, Alberto Broniscer³, Ruitian Song¹, Ralf B. Loeffler¹, Claudia M. Hillenbrand¹

¹Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; ²Biomedical Engineering, University of Memphis, Memphis, TN, United States; ³Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States

An algorithm that combines dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL) imaging for quantitative perfusion measurements was evaluated in a large clinical study in children with diffuse pontine glioma. DSC measurements were calibrated to ASL measurement in voxels with low transit times. An alternative method was evaluated which calibrated DSC to ASL in the gray matter.