Abstract #3978

Regional Biomechanical Property of Intracranial Tissue using Dynamic Diffusion MRI: A Phantom Study

Hirohito Kan¹, Tosiaki Miyati¹, Mitsuhito Mase², Masaki Hara³, Makoto Kawano³, Yuta Shibamoto³, Harumasa Kasai³, Nobuyuki Arai³, Akihiro Kitanaka¹, Risa Yorimitsu¹

¹Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan; ²Department of Neurosurgery & Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan; ³Department of Radiology, Nagoya City University Hospital, Nagoya, Aichi, Japan

To clarify the mechanism, i.e., the fluctuation of the water molecules in the intracranial tissue, we determined the temporal ADC waves obtained with diffusion magnetic resonance imaging (MRI) using a hemodialyzer phantom. Our original phantom makes it possible to analyze the change in ADC due to the volume loading, assess the biomechanical property, and verify the mechanism of the fluctuation of water molecules in the intracranial tissue.