Measurement of Axon Radii Distribution in Orientationally Unknown Tissue using Angular Double-Pulsed Gradient Spin Echo (Double-PGSE) NMR

Wenjin Zhou¹, David Laidlaw¹

We present an analytical diffusion model for measuring axon properties in biological tissue of unknown orientation using low-q angular double-pulsed gradient spin echo (d-PGSE) NMR. The axon properties we aim to recover are axon radii distribution, axon orientation, and axon volume fraction. Our simulation results demonstrate that clinically feasible acquisition protocols are sufficient to accurately recover these axon properties in typical human brain tissue range (1-5m).