On the Time to Peak Factor of Dynamic Susceptibility Contrast of Microbubbles

Shin-Lei Peng¹, Chih-Kuang Yeh¹, Chung-Hsin Wang¹, Hsu-Hsia Peng¹, Fu-Nien Wang¹

Recently, microbubbles were used as a MR susceptibility contrast agent because of the susceptibility differences by the gas-liquid interface. However, the relationship between rCBV deriving from Gd-DTPA and that from microbubbles has not been investigated. In this study, we aim to investigate correlation between rCBV from both contrast agents and find the key factor influencing the correlation. The results showed that the time-to-peak for microbubbles increases, the correlation between microbubbles and Gd-DTPA increases. When time-to-peak of microbubbles increases, it may mean that more microbubbles aggregate and trap in local tissue vasculature. As a result, the stronger susceptibility effect will be produced and lead to high correlate with Gd-DTPA.