Utility of Non-Model Based Semi-Quantitative Indices Derived from Dynamic Contrast Enhanced T1-Weighted MR Perfusion in Differentiating Treatment Induced Necrosis from Recurrent Progressive Brain Tumor.

Jayant Narang¹, Rajan Jain^1,2, Syed Ali Arbab³, Abbas Babajani-Feremi³

The purpose of this study was to assess the utility of non-model based semi-quantitative indices derived from dynamic contrast-enhanced T1-weighted magnetic resonance perfusion (DCET1MRP) in differentiating treatment induced necrosis (TIN) from recurrent/progressive tumor (RPT). Practical impact of DCET1MRP on routine neuro-oncologic imaging practice is limited by the need of complicated multi-compartment physiological models and intensive computational requirements to derive pharmacokinetic metrics and hence, the lack of an easy to use commercially available software. Our results show that these non-model based indices which are relatively easy to derive, robust and reproducible can be effectively used to differentiate TIN from RPT.