Simultaneous PET/MRI: Evaluation of Electromagnetic Interactions & In Vivo Imaging in 9.4 T MRI

Sri-Harsha Maramraju^1,2, S.-David Smith², Sean Stoll², Daniela Schulz², Sergio Rescia², Sachin Junnarkar², Martin Purschke², Bosky Ravindranath^1,2, Paul Vaska^1,2, Craig Woody², David Schlyer^1,2

The electromagnetic interactions between the PET and MRI systems were evaluated by assessing the MR image quality and evaluating the PET performance. Results from the MRS and EPI data show no signs of interference on the MR images during PET acquisition and the PET data were quantitative. Studies were carried out using radiolabeled iron oxide nanoparticles in mice to study the dynamics and biodistribution of nanoparticles in vivo. These studies help to understand the toxicological effects and biological fate of these nanoparticles in vivo.