Abstract #3728

Comparing Different Drug Carriers for Dynamic Absolute MR Thermometry

Roel Deckers¹, Sara M. Sprinkhuizen¹, Marina Talelli², Bart Crielaard², Hans Ippel³, Rolf Boelens³, Twan Lammers^2,4, Chris J. Bakker¹, Gert Storm², Lambertus W. Bartels¹

¹Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; ²Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; ³Department of NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands; ⁴Department of Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany

Dynamic absolute MR thermometry may be of great interest for the precise and accurate control of hyperthermia in local drug delivery applications. We compared different drug carriers that provide a temperature insensitive proton resonance frequency (PRF) that can serve as reference for the temperature sensitive PRF of water. The frequency difference between both PRFs is a measure of the absolute temperature and can be measured with NMR spectroscopy or multi-Gradient Echo (mGE) sequence. The influence of the drug carrier composition and the pH on the NMR signal are measured and the accuracy and sensitivity of the mGE method are investigated.