Abstract #3718

Thermal Ablative Lesions in Sheeps Renal Cortex using Respiratory Gated MRgHIFU: Spatial Accuracy & Complications

Lorena Petrusca¹, Magalie Viallon², Thomas Goget², Denis Morel³, Xavier Montet², Vincent Auboiroux², Sylvain Terraz², Christoph D. Becker², Rares Salomir²

¹Radiology Department, University Hospitals of Geneva , Geneva , Switzerland; ²Radiology Department, University Hospitals of Geneva, Geneva, Switzerland; ³Anesthesiology, University Hospitals of Geneva, Geneva, Switzerland

An in vivo study on sheeps kidney is described here, demonstrating the capability to produce sharply delineated thermal ablations in the renal cortex. Elementary sonications were performed at prescribed locations in the renal cortex using an optoelectronic respiration sensor to trigger the HIFU beam and the multi-planar MR-thermometry. The results obtained showed circular homogenous regions of thermal ablation and were confirmed by kinetic curves taken after the administration of Gd-based contrast agent bolus and also by post-mortem histological analysis. A careful evaluation of the side-effects by MR-thermometry monitoring in 3 orthogonal planes and semi-chronic follow up is mandatory to assess regional biologic reactions and lesions.