Abstract #3701

Monitoring of Iron-PLLA Particle Loaded MSCs After Intramuscular Injection in the Rat Model @ 3T

Volker Rasche¹, Natalie Fekete², Axel Bornstedt¹, Jian Zhu, Ina Vernikouskaya, Martin Urban³, Katharina Landfester³, Gerlinde Schmidtke-Schrezenmeier², Hubert Schrezenmeier²

¹Internal Medicine II, University Hospital Ulm, Ulm, Germany; ²Institute for Transfusion Medicine, University Hospital Ulm; ³Max-Planck-Institute for Polymer Research

Recently the use of Poly-L-Lactic Acid (PLLA) iron loaded nanoparticles for MSC labeling was suggested. These particles were tested for in vivo monitoring of MSC trafficking in rats. The MSCs could be followed over 9 days in vivo with high sensitivitiy.