Abstract #3640

Tumor Induced Alterations in Hemodynamic Responses in BOLD fMRI: Implications in Presurgical Functional Brain Mapping

Liya Wang^1,2, Dandan Chen³, Jeffery Olson⁴, Shazia Ali¹, Tianning Fan⁵, Hui Mao^1,2

¹Radiology, Emory University School of Medicine, Atlanta, GA, United States; ²Center for Systems Imaging, Emory University, Atlanta, GA, United States; ³Physics, Emory University School of Medicine, Atlanta, GA, United States; ⁴Neurosurgery, Emory University School of Medicine, Atlanta, GA, United States; ⁵Center for Systems Imaging, Emory University , Atlanta, GA, United States

The blood oxygenation level dependent (BOLD) fMRI has been widely applied in presurgical planning for brain tumor resection. Growth of brain tumor is commonly accompanied by the abnormal blood perfusion, therefore, may lead to an altered BOLD effect and inaccurate measurement of functional maps. This study investigated the effect of the brain tumor to the HDR and BOLD signal time courses in brain tumor patients and its potential impact to the presurgical brain mapping.