Abstract #3568

Functional Networks in the Macaque Brain Revealed by Independent Component Analysis of Resting-State fMRI

R. Matthew Hutchison¹, L. Stan Leung¹, Seyed M. Mirsattari¹, Joseph S. Gati², Ravi S. Menon², Stefan Everling²

¹University of Western Ontario, London, Ontario, Canada; ²Robarts Research Institute, London, Ontario, Canada

Independent component analysis of the resting macaque brain revealed homologous large-scale network organization at multiple levels of processing with humans. These included higher-order networks facilitating executive functioning, attentional processing, reward evaluation, and default-mode activity as well as lower-order networks responsible for vision, audition, sensorimotor integration, and motor control. The consistency of RSNs between macaques and humans suggests the same gross topological cortical organization, thereby providing strong support for their use as an animal model in the study of normal and abnormal functional connectivity.