Single-Shot, Frequency & Time Specific, 3D Imaging Method for Measuring Hyperpolarized 13C Biomarkers In-Vivo at 14.1 Tesla

Subramaniam Sukumar¹, Kayvan R. Keshari¹, Robert Bok¹, Vickie Zhang¹, Andrew Taylor¹, Michael A. Ohliger¹, Hikari Yoshihara¹, John Kurhanewicz¹, Daniel B. Vigneron¹

Hyperpolarized 13C biomarkers provide unique biochemical information in-vivo but the short lived magnetization requires special pulse sequences for acquiring the MRSI data quickly and efficiently. High field systems pose further challenges because artifacts related to wide chemical shift dispersion, T2* and motion are increased. We developed a novel, single shot, chemical shift specific 3D imaging method which is particularly suited for high field studies involving hyperpolarized 13C biomarkers. We have used the technique for studying various disease models in mice at 14.1T.