Abstract #3528

Effects of RF Excitation Scheme on Signal-To-Noise-Ratio & Apparent Rate Constant Estimation in Dynamic Volumetric Imaging of Hyperpolarized [1-13C]-Pyruvate

Sonal Josan^1,2, Ralph Hurd³, Adam B. Kerr⁴, Yi-Fen Yen³, Peder E. Z. Larson⁵, Adolf Pfefferbaum^1,6, Daniel Spielman², Dirk Mayer^1,2

¹SRI International, Menlo Park, CA, United States; ²Radiology, Stanford University, Stanford, CA, United States; ³GE Healthcare Applied Science Laboratory, Menlo Park, CA, United States; ⁴Electrical Engineering, Stanford University, Stanford, CA, United States; ⁵Dept of Radiology & Biomedical Imaging, UC-San Francisco, San Francisco, CA, United States; ⁶Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA, United States

Dynamic 3D metabolic imaging of hyperpolarized [1-¹³C]-pyruvate requires a large number of RF excitations, which can impact the shape of the dynamic response, the calculation of apparent rate constants, and signal to noise ratio. This work investigates the performance of different flip angle schemes using multi-band RF pulses in multiple organs (brain, liver and kidney) with different tissue perfusion rates and metabolic activities.