Steven Reynolds1, Samira Kazan2,
Leigh Williams2, Aneurin Kennerley3, Jason Berwick3,
Gillian Tozer2, Martyn Paley1
1Academic unit of
Radiology, Medical School, University of Sheffield, Sheffield, S. Yorkshire,
United Kingdom; 2Department of Oncology, Medical School,
University of Sheffield, Sheffield, S. Yorkshire, United Kingdom; 3Department
of Psychology,
Using the sensitivity enhancement of DNP we are using hyperpolarised pyruvate as a biomarker for changes in tumour oxygenation. To improve our model of the pyruvate metabolic flux we have measured the arterial input function (AIF) using the hyperpolarised 13C pyruvate signal from the carotid artery of a BDIX rat. Since AIF is dependent upon the injection condition there was a requirement to provide an automated, rapid, injection system. We have developed an automated injector that can be used close the bore of an unshielded 7T magnet.