Optimized Semi-LASER 3D MRSI Sequence for Lactate Detection in the Prostate

Thiele Kobus¹, Arend Heerschap¹, Tom W. J. Scheenen¹

3D MRSI with adiabatic refocusing pulses was optimized for lactate detection in the prostate. Echo time and inter-pulse delays of the AFP pulses were optimized for an in phase citrate shape and anti-phase lactate signals. Simulations, phantom and in vivo measurements were performed. In 3 patients with advanced prostate cancer lactate signals remained below the minimal detectable lactate levels of around 1 mM.