Improved Spatial Localization in 3D MRSI with a Sequence Combining PSF-Choice, EPSI & a Resolution-Enhancement Algorithm

Lawrence Patrick Panych¹, Bruno Madore¹, William S. Hoge¹, Robert V. Mulkern²

MRSI with PSF-Choice encoding in two directions and with EPSI along the third direction was implemented. PSF-Choice, using a RF manipulation scheme, alters the PSF to obtain a Gaussian shape, eliminating truncation artifact without loss in spatial resolution. With the addition of EPSI, acquisition is accelerated and, during multiple acquisitions to maintain SNR, image data is acquired in such a way that a resolution-enhancement algorithm can be applied. This is possible because of the higher spatial frequency content in the Gaussian-shaped PSF. Results in phantoms on a 3T MRI system were obtained.