Matthias Alexander Dieringer1,2, Michael
Deimling2,3, Davide Santoro2, Flavio Carinci2,4,
Jeanette Schulz-Menger1,2, Thoralf Niendorf1,2
1Experimental and Clinical
Research Center (ECRC), Charit Campus Buch, Humboldt-University, Berlin,
Germany; 2Berlin Ultrahigh Field Facility, Max-Delbrueck Center
for Molecular Medicine, Berlin, Germany; 3Siemens Healthcare,
Erlangen, Germany; 4Department of Physics, Insubria University,
Como, Italy
3D-DESPOT1/2 have been proposed for rapid and accurate T1 and T2 quantification of the brain. A 2D cardiac application with short repetition times (TR) evokes T1 and flip angle dependent saturation phenomena that deform the slice profile and hence bear the potential to render T1/T2 quantification inaccurate. Although these phenomena are known for several years its impact on T1 and T2 quantification using DESPOT has not been examined yet. This study examines the impact of slice profile deformation on the signal of 2D FLASH and 2D b-SSFP and demonstrates its implications for rapid T1 and T2 quantification using DESPOT1/2.