Abstract #3380

Pancreatic Exocrine Function & Cardiac Iron in Patients with Iron Overload & with Thalassemia

Jin Yamamura¹, Regine Grosse², Andrea Jarisch³, Gritta E. Janka⁴, Peter Nielsen⁵, Gerhard Adam¹, Roland Fischer^5,6

¹Diagnostic & Interventional Radiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ²Pediatric Hematology & Oncology, University Medical Center Hamburg-Eppendorf; ³Stem Cell Transplant Center, Johann Wolfgang Goethe-University of Frankfurt, Frankfurt, Germany; ⁴Pediatric Hematology & Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ⁵Department of Biochemistry & Molecular Biology II: Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ⁶Childrens Hospital & Research Center Oakland, Oakland, CA, United States

In patients with iron overload, assessment of cardiac iron by fast MRI-R2/R2* methods has become a standard of care. We measured R2* relaxation rates in the myocardium by MRI in comparison with the exocrine pancreatic function by means of serum pancreatic enzyme determination in patients with -thalassemia.Patients at risk of elevated cardiac iron levels could be identified by the exocrine pancreatic lipase and amylase function parameters.