Abstract #3273

Evaluation of Vessel Area using Time-Of-Flight MR Angiography, Contrast-Enhanced MR Angiography & CT Angiography in a Rabbit Peripheral Arterial Disease Model

Yi Xu¹, Yingli Fu¹, Nicole Azene¹, Dorota Kedziorek¹, Tina Ehtiati², Aaron Flammang², Bruce A. Wasserman¹, Ye Qiao¹, Merine Etesami¹, Steven M. Shea², Dara L. Kraitchman¹

¹Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University, Baltimore, MD, United States; ²Center for Applied Medical Imaging, Siemens Corporate Research, Inc., Baltimore, MD, United States

Measurement of small vessel diameters by MRA is challenging especially in ischemic disease. Our purpose was to compare vessel area measurement by TOF-MRA, ce-MRA and CTA after transplantation of mesenchymal stem cells in an animal peripheral arterial disease model. Both MRA techniques could provide an acceptable precision to measure small vessel diameters without ionizing radiation for the evaluation of an arteriogenesis therapy efficiacy.