Abstract #3268

Assessment of Changes in Regional Distribution of Skeletal Muscle Adipose Tissue in Type 2 Diabetes using Quantitative IDEAL Gradient Echo Imaging

Dimitrios C. Karampinos¹, Thomas Baum¹, Lorenzo Nardo¹, Julio Carballido-Gamio¹, Paran S. Yap¹, Huanzhou Yu², Ann Shimakawa², Thomas M. Link¹, Sharmila Majumdar¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

Changes in adipose tissue compartmentalization within skeletal muscle have been observed in patients with type 2 diabetes. Segmentation of T1-weighted images has been traditionally used to characterize these changes with significant limitations in quantifying fat content alterations in localized muscle anatomical regions. Quantitative chemical shift-based water/fat separation, like IDEAL gradient echo imaging, enables fat quantification with the spatial resolution of conventional imaging. In the present study, quantitative IDEAL is applied in a study of 46 post-menopausal women to investigate changes in regional distribution of calf muscle adipose tissue between controls and patients with type 2 diabetes.