Reduced T2* Values in Soleus Muscle of Type 2 Diabetes Mellitus

Chun S. Zuo¹, Donald Simonson², Young-Hoon Sung¹, Rosemond Villafuerte¹, Perry F. Renshaw¹

We have examined T2* of soleus in Type 2 Diabetes Mellitus (T2DM) compared to that of normal healthy subjects in a cross-sectional study. We found that soleus T2* is significantly correlated with age and the presence of diabetes. Among factors that may contribute to T2* values, the lowered T2* value in the T2DM soleus muscle is most consistent with poor regional microvascular circulation which suggests that the T2DM soleus is likely under tissue oxygenation stress.