Abstract #3215

The Relationship between Knee Cartilage MR T2 & Morphology in Subjects from the Incidence & Control Cohorts of the Osteoarthritis Initiative

Gabby B. Joseph¹, Thomas Baum¹, Julio Carballido-Gamio¹, Lorenzo Nardo¹, Warapat Virayavanich¹, Hamza Alizai¹, Michael C. Nevitt², John A. Lynch², Charles E. McCulloch², Sharmila Majumdar¹, Thomas M. Link¹

¹Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; ²Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, CA, United States

The purpose of this study is to 1) compare the prevalence of focal knee abnormalities, the mean cartilage MR T₂ relaxation time, and the spatial distribution of cartilage MR T₂ relaxation times between subjects from the control and incidence cohorts of the OAI, and 2) determine the relationship between MR cartilage T₂ parameters and cartilage morphology. The results indicate no significant difference in the prevalence of knee abnormalities (cartilage lesions, BME, meniscus lesions) between the incidence and control groups; however, T₂ parameters (mean T₂, GLCM contrast, and GLCM variance) were significantly elevated in the incidence group.