Jinyuan Zhou1,2, Silun Wang1,
Betty Tyler3, Rachel Grossman3, Erik Tryggestad4,
Eric Ford4, Michael Armour4, Kun Yan1,
Bachchu Lal5, Peter C. M. van Zijl1,2, John Laterra5
1Department of Radiology,
Johns Hopkins University, Baltimore, MD, United States; 2F.M.
Kirby Research Center for Functional Brain Imaging, Kennedy Krieger
Institute, Baltimore, MD, United States; 3Department of
Neurosurgery, Johns Hopkins University, Baltimore, MD, United States; 4Department
of Radiation Oncology, Johns Hopkins University, Baltimore, MD, United
States; 5Department of Neurology, Kennedy Krieger Institute,
Baltimore, MD, United States
We applied APT imaging to U87MG tumor-bearing rats that were treated with radiation therapy (40 Gy). It was found that the APT signal in the radiated tumor significantly decreased after treatment. Our results show the potential of the APT-MRI signal as a biomarker that can greatly improve the value of MRI in the differentiation between viable tumor and radiation necrosis, and in the early prediction of treatment response in brain tumors.