Abstract #3145

Lipid Profile of Distinct Areas of Astrocytic Brain Tumors

Frauke Nehen¹, Laura Columbano², Rudolf Fahlbusch², Dieter Leibfritz¹

¹Institute of Organic Chemistry, University of Bremen, Bremen, Germany; ²International Neuroscience Institute Hannover, Hannover, Germany

Changes of the lipid profile of distinct localisations of high grade astrocytic tumours were analyzed with high resolution ¹H-NMR-spectroscopy. Extracts of active tumor core, tumor margin and more distant tumor margin differ significantly in their content of phosphatidylcholines, plasmalogens, triglycerides and cholesteryl esters. Solid phase extraction revealed a modified fatty acid composition in the tumor core. In addition, galactosyl cerebrosides and dolichols are metabolic discriminators.