Characterization of SCUBE3 Protein for Its Role in Tumor Vascularization by SSCE-MRI

Cheng-Hung Chou¹, Yi-Fang Cheng¹, Amit Kumar¹, Konan Peck¹, Chen Chang¹

Signal peptide-CUB-EGF-like domain containing protein 3 (hSCUBE3) was found to be up-regulated in highly invasive lung cancer cell lines and in patients with poor prognosis; however the functions of hSCUBE3 in lung cancer progression is not clear yet. In this study, steady-state-contrast-enhanced MRI (SSCE-MRI) was used to evaluate the blood vessel structure in xenograft tumors in NOD-SCID mice transplanted with lung adenocarcinomar cells with and without hSCUBE3 knockdown.