Abstract #3090

Chemical Exchange Saturation Transfer (CEST) MRI of the Breast at 3T using Amide Proton Transfer (APT)

Adrienne N. Dula^1,2, Lori R. Arlinghaus^1,2, Bennett A. Landman^1,3, Richard D. Dortch^1,2, John C. Gore^1,2, Tom E. Yankeelov^1,2, Seth A. Smith^1,2

¹Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States; ²Radiology & Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States; ³Electrical Engineering & Computer Science, Vanderbilt University Medical Center, Nashville, TN, United States

We used chemical exchange saturation transfer (CEST) MRI to examine fibroglandular (FG) and tumor tissue of the breast at 3T. Examination of z-spectra asymmetry at the amide proton resonance (3.5ppm) demonstrated heterogeneity of healthy FG tissue and an increase in tumor. As CEST measurements are reflective of the molecular composition of tissue, they may reflect tissue properties that change during the course of disease and treatment.