Abstract #3058

Correlation between In Vivo 1H MRSI & Ex Vivo 1H HR MAS in Spatially Matched Regions in Prostate Cancer Patients

Kirsten Margrete Selns¹, Ingrid Susanne Gribbestad¹, Helena Bertilsson^2,3, Alan Wright⁴, Anders Angelsen³, Arend Heerschap⁴, May-Britt Tessem¹

¹Department of Circulation & Medical Imaging, NTNU, Trondheim, Norway; ²Department of Laboratory Medicine & Children's & Women's Health, NTNU, Trondheim, Norway; ³Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway; ⁴Department of Radiology, Radboud University Nijmegen Medical Centre, Netherlands

Both in vivo and ex vivo spectroscopy are important in prostate cancer handling, with elevated (Choline+Creatine)/Citrate indicative of cancer. So far no studies have investigated the correlation of in vivo and ex vivo measurements in matched regions of the same prostate cancer patient. In this study ex vivo HR MAS spectra were compared to in vivo MRS spectra in spatially matched regions in the same prostate cancer patient. CC/C ratios from in vivo MRS and ex vivo HR MAS were significantly correlated with r=0.63. Both in vivo and ex vivo CC/C were significantly correlated to Gleason grade (r=0.62 and 0.65)