Abstract #3048

DCE-MRI Perfusion in Liver Disease with 3D Volumetric Coverage

Yin Huang¹, Ethan Brodsky¹, Kevin Johnson¹, Eric Bultman², Debra Horng^1,3, Sean Fain^1,3, Scott Reeder^1,3

¹Medical Physics, University of Wisconsin Madison, Madison, WI, United States; ²Biomedical Engineering, University of Wisconsin Madison, Madison, WI, United States; ³Radiology, University of Wisconsin Madison, Madison, WI, United States

A novel method for acquiring dynamic contrast-enhanced (DCE) MRI of liver perfusion with full abdominal coverage is used to measure the blood supply to liver parenchyma and focal liver lesions non-invasively. This study aims to provide semi-quantitative metrics to evaluate 3D regional perfusion in a feasibility study to measure perfusion in focal liver lesions. The method is designed to predict long-term tumor response to chemotherapy by providing quantitative measures of early changes in perfusion specific to liver tumors.