Optimising Oral Contrast Agents for Interactive Neonatal Gut Imaging

Owen John Arthurs¹, Martin John Graves¹, Ilse Joubert¹, David John Lomas¹

The optimal contrast medium for neonatal gut MR imaging is unclear. Here, we investigate the relative T1 properties of several different potential agents to provide optimal signal. We then tested a variable IR pulse during interactive SSFSE imaging to existing bowel fluid and demonstrate feasibility. An optimal in-vitro TI of 500 - 800ms gave maximal signal difference between pineapple juices and milk, but in-vivo this was 1000 ms. Application of an optimally timed IR pulse can allow for improved contrast medium imaging in this sensitive population.