Abstract #2996

Metabolite Cycled Non-Water-Suppressed Spectroscopy Offers Increased Spectral Quality in Cases of Physiologic & Subject Motion

Erin Leigh MacMillan¹, Murielle Bortolotti², Andreas Boss¹, Chris Boesch¹, Roland Kreis¹

¹Dept. of Clinical Research, University of Bern, Bern, Switzerland; ²Dept. of Physiology, University of Lausanne, Lausanne, Switzerland

Metabolite cycled non-water-suppressed MRS enables automatic phase, frequency, and eddy-current correction of individually acquired spectra to improve SNR and lineshape of metabolite peaks. Examples from deliberate motion of the head and respiratory motion of the liver show remarkable improvement in both SNR and linewidth. The median FWHM of the liver spectra water peak was improved from 18Hz (range: 13-36Hz) to 15Hz (13-22Hz), demonstrating how this technique performs particularly well with decreasing quality of the originally measured spectra. The improved spectral quality will help make MRS more applicable in the clinic, especially in cases of subject or physiologic motion.