The Effect of Fat Suppression on ADC Values in Murine Liver with Variable Degrees of Fibrosis

Stephan William Anderson¹, Jorge A. Soto¹, Elizabeth Tang¹, Hernan Jara¹

Purpose: The determine if fat suppression(FS) pulses influence ADC values and whether effects vary based on degrees of fibrosis in murine liver. Methods: 3,5-dicarbethoxy-1,4-dihydrocollidine was utilized to induce hepatic fibrosis. Liver specimens were imaged using 11.7T MRI; ADC values with and without fat suppression were compared and differences correlated with hepatic fibrosis. Results: Slight differences in ADC values derived with FS were seen; poor correlation was seen between differences in ADC and degrees of fibrosis. Conclusion: The difference in ADC values with and without FS is not a confounding effect in deriving ADC values of the liver with variable fibrosis.