Assessment of Renal Function by ASL in Wilms Tumor Survivors

Ruitian Song¹, Ralf B. Loeffler¹, Mary Beth McCarville¹, Sheri L. Spunt², Claudia Maria Hillenbrand¹

Renal blood flow (RBF) rates and glomerular filtration rate (GFR) were measured using arterial spin labeling (ASL) and creatinine clearance (CrCl) tests, respectively, in 23 long-term survivors of unilatral Wilms tumor. Correlations between GFR and RBF were examined in radiotherapy, non-radiotherapy groups. r= 0.78 was found in all the patients. The correlation in the non-radiotherapy group (r=0.89) was better than that in the radiotherapy group (r=0.68). The radiation damage may enhance the probability for unstable renal function, which may cause the measured GFR values be less reliable and thus the weaker correlation. ASL may be a better indicator for renal function.