Abstract #2956

Evaluation of Intra-Renal Oxygenation by BOLD MRI During Water Diuresis: Race Differences

Lu-Ping Li¹, Federico Mordini², Sarah Halter¹, Eugene Dunkle¹, JoAnn Carbray¹, Ewa Gliwa¹, Hongyan Du³, Pottumarthi V Prasad¹

¹Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL, United States; ²Radiology / Center for Advanced Imaging, Northshore University Healthsystem, Evanston, IL , United States; ³Center for Clinical Research Informatics (CCRI), Research Institute, Northshore University Healthsystem, Evanston, IL, United States

Prevalence of hypertension is significantly higher in the African American (AA) population compared to Caucasian (CC). A role for endothelial dysfunction has been shown based on Brachial artery ultrasonography (BAUS). Since response to water-loading on renal medullary oxygenation evaluated by BOLD MRI is also dependent on endogenous mechanisms such as prostaglandins and nitric oxide, we performed a preliminary study to evaluate these differences in a small number of healthy AA and CC. BAUS data was also obtained. Both BAUS and BOLD MRI data show reduced responses in AA, although our sample size is small to reach statistical significance.