Abstract #2930

Assessment of Hepatic Perfusion with Diffusion Weighted & Dynamic Contrast Enhanced 1H MRI in CCl4 Treated Rat Liver

Andriy Babsky¹, Beena George¹, George Sandusky², Navin Bansal¹

¹Radiology & Imaging Sciences, Indiana University, Indianapolis, IN, United States; ²Pathology & Laboratory Medicine, Indiana University, Indianapolis, IN, United States

Use of diffusion-weighted (DW) and dynamic contrast enhanced (DCE) ¹H MRI for the assessment of hepatic perfusion and diffusion parameters were evaluated in a CCl₄-induced rat liver injury model. CCl₄-induced liver injury caused decreases in both fast and slow apparent diffusion coefficient of water measured by DW MRI, as well as a decrease in contrast agent uptake measured by DCE MRI. DW ¹H MRI should prove useful in assessment of liver damage in diffuse liver diseases without the need for a contrast agent.