Xianfeng Shi1,2, Young-Hoon Sung3,4,
SeongEun Kim2, Perry Renshaw3,4, Eunkee
Jeong2
1The Brain Institute,
University of Utah, Salt Lake City , UT, United States; 2Department
of Radiology, University of Utah, Salt Lake City, UT, United States; 3The
Brain Institute, University of Utah, Salt Lake City, UT, United States; 4Department
of Psychiatry, University of Utah, Salt Lake City, UT, United States
Creatine Kinase (CK) is widely present in human brain tissues. It catalyzes the conversion between phosphocreatine (PCr) and adenosine diphosphate (ATP). Thus CK reaction rate constant (kf) is an indicator of the brain neuronal activity. A method using ISIS and a saturation recovery process provides accurate measurement of kf within 40 minute data acquisition, which is mostly spent to measure the apparent T1 relaxation time. The long acquisition time prevents its routine application. In this report, a new pulse sequence ISIS with simultaneous spin echo and stimulated Echo (ISIS-sSESTE) is developed to rapidly measure the 31P T1 relaxation time.