Optimized CEST Imaging of Intermediate to Fast Exchanging Agents in In-Vivo Situations

Anup Singh¹, Hari Hariharan¹, Kejia Cai¹, Mohammad Haris Haris¹, Ravinder Reddy¹

In this study, optimization of saturation pulse amplitude and duration for in-vivo CEST imaging of intermediate to fast exchanging molecules is demonstrated using numerical simulations of Bloch-McConnell equations. High B1 amplitude and short duration of saturation pulse provides optimum CEST contrast with minimized contamination from slow exchanging agents and reduced SAR.