High Resolution Imaging of Myo-Insitol in Alzhemiers Disease Pathology

Mohammad Haris¹, Anup Singh¹, Kejia Cai¹, Kavindra Nath², Rachelle Berger¹, Ari Borthakur¹, Hari Hariharan¹, Ravinder Reddy¹

The concentration of MI has been shown to change in Alzheimers disease (AD) pathology. Earlier, whole brain mapping of MI has been performed using chemical exchange saturation transfer (CEST) imaging. Here, we mapped the change in MI concentration, at high resolution, in transgenic AD mice brain (APP/PS1, n=3) using CEST technique. Compared to wild type mice (n=2), AD mice showed a significant increased MICEST contrast, which was also in good agreement with the changes in proton spectroscopy of MI. This method potentially provides a quantitative tool for measuring early molecular changes associated with the disease progression in AD.