Chemical Exchange Saturation Transfer Effect from Phospho-Creatine (PCr) & Adenosine-Tri-Phosphate (ATP)

Mohammad Haris¹, Kejia Cai¹, Anup Singh¹, Victor Babu Kc¹, Hari Hariharan¹, Ravinder Reddy¹

In the current study, we define the chemical exchange saturation transfer (CEST) effect from phospho-creatine (PCr) and adenosine-tri-phosphate (ATP). PCr showed CEST effect at ~2.5ppm while ATP at ~2.0ppm. CEST imaging at different concentration PCr and ATP solutions was performed and mapped. We are in process of implementing the current technique to investigate mapping of PCr and Cr in-vivo on human calf muscles both at 3T and 7T and monitor exercise related changes in these metabolites.