Fast Proton Density Mapping using Bias Field Correction

Steffen Volz¹, Ulrike Nth¹, Ralf Deichmann¹

A method for fast mapping of the proton density (PD) is presented, based on advanced analysis of data obtained with the variable flip angle technique. In particular, corrections for the sensitivity profile of the receiver coil are performed by creating a synthetic T1 weighted anatomical image where all other sources of signal non-uniformities have been removed. Thus, correction factors can be directly deduced from the bias field following from unified segmentation of the synthetic anatomy. Numerical PD values obtained from six subjects are in very good agreement with literature values.