Reference Free Localization & Quantification of Contrast Agents using Relaxivity Dispersion at 1.5T

Uvo Christoph Hoelscher¹, Steffen Lother¹, Florian Fidler¹, Peter Jakob^1,2

Many medical problems can benefit from unambiguous localization and quantification of contrast agents, but conventional detection / quantification methods always require reference scans to separate contrast agent and tissue. In this work we present a new method to acquire both information without the need for a reference scan. The technique exploits relaxivity dispersion of the contrast agent making separation between contrast agent and tissue unambiguous. Resulting images show pure contrast agent signal and can be used to determine concentrations.