Abstract #2662

Quantitative Susceptibility Mapping of Cerebral Microbleeds

Tian Liu^1,2, Krishna Surapaneni³, Min Lou⁴, Liuquan Cheng⁵, Jianzhong Sun⁶, Cynthia Wisnieff ^{1, 2}, Craig Horenstein³, Minming Zhang⁶, Yi Wang^1,2

¹Biomedical Engineering, Cornell University, Ithaca, NY, United States; ²Radiology, Weill Cornell Medical College, New York, NY, United States; ³Radiology, Columbia University, New York, NY, United States; ⁴Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, China, People's Republic of; ⁵Radiology, PLA General Hospital, Beijing, China, People's Republic of; ⁶Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, China, People's Republic of

Gradient echo(GRE) MRI is the method of choice for detecting cerebral microbleeds(CMB) due to its sensitivity to the paramagnetic intreaparenchymal hemosiderin deposits. However, the hypointensity associated with CMB on a GRE image is highly dependent on the choice of echo time. In this study, we propose to use quantitative susceptibility mapping(QSM) as a more objective measurement of CMBs because the underlying susceptibility is theoretically independent of imaging parameter. Comparison of the T2* weighted image (T2*w), susceptibility weighted image (SWI) and R2* map showed the total susceptibility of a CMB varies the least with varying TEs.