Glutamate Correlations between the Anterior Cingulate & Cerebellar Vermis

Kevin Wayne Waddell¹, Subechhya Pradhan², Malcolm Avison¹, John Gore³

Correlation networks among brain metabolites in the anterior cingulate (AC) and cerebellar vermis (CV) were measured with J-difference MRS. Glutamate varied linearly (r =0.61, p = 0.01) between the AC and the CV and additional inter-regional correlations were absent. Within both regions, correlations were observed between metabolites which were weakly significant when correcting for multiple comparisons (NAA and Glu; AC: r = 0.66, p = 0.01; CV: r = 0.64, p = 0.01). Correlations between and within these regions are potentially interesting and may enable further differentiation among disorders that involve the AC and CV acting in concert.