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Abstract #2433

Assessment of Tumor Perfusion by DSC MRI During Radiation Therapy in Children with Diffuse Intrinsic Pontine Glioma

Adam M. Winchell1,2, Mehmet Kocak3, Hoang-Vu Tran1, Ruitian Song1, Ralf B. Loeffler1, Alberto Broniscer4, Claudia M. Hillenbrand1

1Radiological Sciences, St. Jude Children's Research Hospital, Memphis, TN, United States; 2Biomedical Engineering , University of Memphis, Memphis, TN, United States; 3Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, United States; 4Oncology, St. Jude Children's Research Hospital, Memphis, TN, United States


Dynamic susceptibility contrast (DSC) perfusion imaging was performed to investigate a preliminary understanding of vascular proliferation of the tumor during RT. The objective of this study was to study the evolution of perfusion using DSC during treatment of DIPG to provide markers of disease response and progression.