Abstract #2428

Initial Experience with Vessel Size Imaging in Recurrent Glioblastoma Multiforme using a Multiple Spin & Gradient Echo (SAGE) Perfusion Bolus Contrast Sequence

Jalal Badi Andre¹, Heiko Schmiedeskamp¹, Greg Zaharchuk¹, Matus Straka¹, Thomas Christen¹, Lawrence Recht², Roland Bammer¹

¹Radiology, Stanford University, Stanford, CA, United States; ²Neuro-Oncology, Stanford University, Stanford, CA, United States

This retrospective pilot study highlights our initial experience using a combined multiecho spin and gradient echo (SAGE) EPI sequence during bolus contrast that allows direct evaluation of R2 changes to R2* changes for vessel size imaging (VSI). This SAGE technique was used in patients with pathologically proven GBM, and applied to address the question of tumor recurrence versus radiation necrosis in the hope of identifying a more sensitive method to detect tumor recurrence, thus enabling more timely modification of therapy and improved prognosis.