Jens Rosenberg1,2, Ali Darkazalli3,
Cathy W. Levenson3, Samuel Colles Grant1,2
1National High Magnetic
Field Laboratory, The Florida State University, Tallahassee, FL, United
States; 2Chemical & Biomedical Engineering, The Florida State
University, Tallahassee, FL, United States; 3Biomedical Sciences,
The Florida State University, Tallahassee, FL, United States
This study investigates if magnetically labeled neuroprogenitor cells (NPC) from the subventricular zone (SVZ) will deviate from migration along the rostral migratory stream (RMS) to address neuronal damage resulting from traumatic brain injury (TBI). Results indicate that TBI did not impact the cellular uptake of micron sized magnetic particles but potentially slowed migration along the RMS and re-routed NPCs and their progeny to damaged areas. The necrotic cores of TBI lesions show dark contrast in the periphery, which partially represent cells migrating from the SVZ to the TBI as part of either inflammatory response or regeneration in the lesion penumbra.