Dan Xu1, Hsiao-Fang Liang2,
Wei-Xing Shi, Shu-Wei Sun3
1Pharmaceutical Sciences
& Basic Sciences, Schools of Pharmacy & Medicine, Loma Linda
University, Loma Linda, CA, United States; 2Biophysics & Bioengineering,
Loma Linda University; 3Biophysics & Bioengineering, Loma
Linda University, Loma Linda, CA, United States
Diffusion tensor imaging (DTI) and visual evoked potential (VEP) recording were performed in mice with chronic experimental autoimmune encephalomyelitis (EAE), an animal model of optic neuritis. Correlation analysis showed that VEP amplitudes were significantly correlated with DTI indices of the optic nerves and optic tracts, providing the evidence that microstructural changes detected by DTI are associated with functional alteration.