Early Anatomical & Microstructural Changes Induced in Rat Brain by Vitamin a Deprivation: A Longitudinal MRI Study

Bassem Hiba¹, Bader Chaarani¹, M. C. Beauvieux¹, G. Rafard¹, Michle Allard², Alan Stephant¹, Jean Michel Franconi¹, Jean Louis Gallis¹

The aim of this work is to follow-up the earliest brain changes from the onset of vitamin A deprivation (VAD) in a rat model of brain degenerative process, using diffusion tensor imaging and anatomical MRI. 4 rats with VAD and 4 control rats were followed once a week along the first 6 weeks of VAD.